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Bite me: Venom, volunteers and venture capital

A maverick’s self-inflicted snake bites could unlock breakthrough treatments – but they also reveal deeper tensions between noble scientific curiosity and cold corporate callousness, write ROX MIDDLETON, LIAM SHAW and MIRIAM GAUNTLETT

POISON: Centivax workers study antivenom to counteract the bites of various snakes at the company lab in San Francisco

IN the 1660s, the Italian natural philosopher Francesco Redi started to investigate vipers at the urging of the Grand Duke of Tuscany. In his final work, Redi criticised previous writers on the topic, accusing them of parroting received wisdom.

One popular belief among scholars was that viper bile, produced in the snake’s liver, was also poisonous. Redi referred to a demonstration by a viper catcher who, after listening to the learned debate, “took a viper’s bile and diluting it with half a glass of fresh water, tossed it off with unflinching face; he gave to understand how mistaken the above-mentioned authors were.”

There is a rhetorical power to self-experimentation — particularly if it is dangerous. To see if colours were produced by pressure, Isaac Newton rammed a bodkin into his own eye. The Scottish surgeon John Hunter inoculated himself with pus from a patient with gonorrhoea to see if he would later get syphilis.

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